About Us - Mission, Aim And Vision

We aspire to aid the community in leading a healthy life through affordable & accessible medication
akurab Healthcare provides a complete range of services  to support the pharmaceutical industry.
our offerings span in Antibiotics, Antifungals, Gastrointestinals, NSAIDs, Anthelmintics, Cardiovascular, Dermal and other categories.

Our strong portfolio of products covers specialties of doctors right from G.P to Super Specialties in India.

its a  company with a policy of Reliability, Honesty and Integrity.

Our Mission

"To support a healthy & active lifestyle of the community through affordable, accessible and best quality medications"

Our Vision

"To be among the top 10 Pharma Companies of India by 2020."


Quality Assurance

 "Taking into consideration the international standards, akurab healthcare ensures that at the manufacturing units all the products should pass through stringent
 quality checking procedures.For maintaining quality of our gamut of products, our manufacturing partners have been rewarded with GMP and ISO 9001 certifications.
 we emphasize prevention of defects rather than relying on detection and correction.our policy is zero tolerance for any defects. "


Innovative thinking

"The pharmaceutical business world has been flattened by globalization, changing demographics, ubiquity of technology, and regulatory compliance. Conducting
business in this level  requires a change in mindset, strategies and operations.our Policy is
Think and innovate faster,always Think about winning through right means,Marketing Optimization ,Cost Optimization ,no compromise on quality etc"



Environment friendly

"akurab healthcare is committed in the highest regard, to protecting our employees, the community, and the environment through comprehensive environmental,
 health, and safety policies. akurab Healthcare is also committed to developing and promoting methods of waste reduction and recycling in the interest of
minimizing undesirable effects on air, water, land, and human health."

Careers- come join and Grow With Us.

"we proudly employ unique and dedicated individuals that value teamwork, integrity, and innovation. We strive to empower our employees
to continue their personal and career growth through our continuous training, advancement opportunities and robust tuition reimbursement policy. We cultivate
 a dynamic team environment that encourages quality-at-the-source, the can-do spirit, and outstanding customer service."

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APPICAL A cap

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each soft gelatin capsule of APPICAL A contains:
alfa calcidol            0.25 mcg
calcium carbonate     200 mg


CATEGORY nutritional - calcium supplement


MODE OF ACTION

Alfa calcidol - Alfacalcidol is a precursor of the active calcitriol. It does not require renal hydroxylation but requires 25-hydroxylation in the liver for conversion to calcitriol . t gets  converted in liver to calcitriol.wihich in turn increases the calcium absorption.

Calcium - Calcium in the blood has many important roles to play: it transports nutrients across cell membranes; produces hormones and enzymes involved in digestion and metabolism; is involved in nerve cell communication; promotes blood clotting and woundhealing; and assists with muscle contractions.


INDICATIONS

Renal osteodystrophy ( defective mineralisation due to kidney disease)
Hypoparathyroidism
Secondary hyperparathyroidism
Osteoporosis
Rickets or osteomalacia

DOSAGE 1 Capsule BD or as directed by the physician.


CONTRAINDICATIONS

Hypercalcemia ,Hypersensitivity.


PRECAUTIONS

Pregnancy, lactation, renal impairment, infants, elderly


SALIENT FEATURES

Alfa calcidol is inactive synthetic metabolite of vitamin D. It increases the level of calcium slowly after getting converted to active form and therefore does not produce hypercalcemia.
alfa calcidol works independently of kidney and PTH.



WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Anti fungal range

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

VINJA TAB                     Fluconazole 50,150 mg


WARNING!

Be sure to consult your doctor before taking any medication!


"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Dermatological

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only


AKUDERM  F                Sodium fusidate 2 % w/w


AKUDERM 3                 Clobetasol 0.05% w/w+Neomycin 0.5% w/w+
                                     Clotrimazole 1%w/w

AKUDERM MO             Mometasone Furoate 0.1% w/w


AKUDERM CN              Clobetasol 0.05% w/w+Neomycin 0.5% w/w


AKUDERM CS               Clobetasol 0.05% w/w+Salicylic acid 3% w/w






WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Laxative

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

LXFLO SUSP.              Milk of Magnesia 3.75 ml + Liquid Paraffin 1.25 ml
                                                   Sodium Picosulfate 3.33 mg


WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Antihelmintic range

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

WORNO SUSP.                Albendazole - 200mg

WORNO TABLET             Albendazole - 400mg

WORNO V SUSP              Ivermectin - 1.5 mg Albendazole - 200 mg

WORNO V TABLET          Ivermectin - 6 mg Albendazole - 400 mg

WORNO V2 TABLET        Ivermectin - 12 mg Albendazole - 400 mg

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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ZIGOVIT syrup

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each 15 ml (one tablespoonful ) of  ZIGOVIT syrup contains:

Mecobalamine                               500mcg

Vit B6                                             1.5 mg

Niacinamide                                   45 mg

Biotin                                             300 mcg

Zinc                                               10 mg

Iron                                               18 mg

Potassium iodide                           75 mcg

Copper                                         0.45 mg

Manganese                                   1.5 mg

Chromium                                     25 mcg

L-lysine                                         50 mg

Selenium                                      40 mcg

Vit D3                                            200 I.U.

CATEGORY       multivitamin and minerals supplement

INDICATIONS
1 general debility/weakness
2 febrile illness
3 anaemia
4 glossitis
5 neuropathies
6 rickets and osteomalacia (softening of the bones)

DESCRIPTION

METHYLCOBALAMIN ( active form vit. B12 )

useful for the long term treatment of pernicious anaemia
maintains healthy nervous system
essential for cell groth and replication
resolves the symptoms like fatigue,apathy,dizziness,debility and glossitis

PYRIDOXINE ( VIT. B6 )

useful in blood cell formation,improves immune system
low levelsof pyridoxine leads to weakness,glossitis,cheilosis ( cracking at the corners of the mouth ) and anemia.
in children pyridoxine deficiency is an important cause of seizures
deficiency of pyridoxine leads to secondary niacin ( vit. B 3 ) deficiency.

NIACINAMIDE ( VIT. B3 )

important for circulation and healthy skin,stabilizes cholesterol levels and maintains the nervous system.
deficiency leads to anorexia, weakness,weight loss, glossitis,stomatitis and pellagra.

BIOTIN

biotin is used in cell growth,the production of fatty acids,metabolism of fats and proteins and thus releases energy from food
biotin is also helpful in maitaining a steady blood sugar level
biotin deficiency results in dry scaly skin,fatigue,loss of appetite ,nausea,vomitin,mental depression and glossitis

ZINC

zinc is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function , protein synthesis , wound healing , DNA synthesis , and cell division . it also supports normal growth and development during pregnancy, childhood, and adolescence and is required for proper sense of taste and smell .Zinc deficiency is characterized by growth retardation, loss of appetite, and impaired immune function. In more severe cases, zinc deficiency causes hair loss, diarrhea, delayed sexual maturation, impotence, hypogonadism in males, and eye and skin lesions . Weight loss, delayed healing of wounds, taste abnormalities, and mental lethargy can also occur

IRON

iron is necessary for hemoglobin formaion
deficiency of iron may lead to anemia

IODINE

iodine deficiency disorders include endemic goiter,intellectual deficit,spasticity,impaired mental function in children and adults.

COPPER

copper deficiency includes neutropenia,anemia,osteoporosis and fracture of long bones

MANGANESE

manganese deficiency can lead to bone demineralization,poor growwth,ataxia and convulsions

CHROMIUM

chromium potentiates the action of insulin in patients with impaired glucose tolerance.in addition,in some patients,improvement in blood lipid profiles has been reported

L-LYSINE

L-lysine is an essential amino acid thatcan not be produced by thebody from other nutrients. it helps ensure adequate absorption of calcium and the formation of collagen
for bone,cartilageand connective tissue,lysine strengthens circulation and helps the immune system manufacture antibodies.it is necessary for all amino acid assimilation and assists in fat storage
deficiency of lysine can cause fatigue,nausea,anemia,tiredness,dizziness,loss of appetite and stunted growth.

SELENIUM

selenium serves to protect proteins,cell membranes,lipids and nucleic acids from oxidant molecules

VITAMIN D

vitamin D a fat soluble vitamin that regulates calcium and magnesium metabolism in the body.
Vitamin D promotes intestinal absorption of calcium, mobilization of calcium from bone stores, and retention of calcium by the kidneys. It is therefore essential for the calcification of bones and teeth.
New research has also found Vitamin D inversely associated with the incidence of upper respiratory tract infections

DOSAGE

Adults      2  Tsf   bd
Children  1  Tsf   bd

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Appical tablet

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each film coated tablet of APPICAL contains :

Calcium carbonate IP
eqv. to elemental calcium                500 mg

Magnesium hydroxide IP
eqv. to elemental magnesium           75 mg

Zinc sulphate monohydrate  USP
eqv to elemental zinc                        4 mg

Vitamin D3 IP                                  250 IU

CATEGORY calcium supplements

Calcium in the body is found stored in the bones and teeth, a small amount is also found in the bloodstream Calcium in the blood has many important roles to play: it transports nutrients across cell membranes; produces hormones and enzymes involved in digestion and metabolism; is involved in nerve cell communication; promotes blood clotting and woundhealing; and assists with muscle contractions.

Magnesium also plays an important role in maintaining the function of nerves and regulating muscle relaxation. A deficiency in magnesium is associated with the occurrence of muscle spasms, tremors and convulsion.Low magnesium levels have also been associated with psychiatric problems such as depression and schizophrenia

Vitamin D is a fat soluble vitamin that regulates calcium and magnesium metabolism in the body.
Vitamin D promotes intestinal absorption of calcium, mobilization of calcium from bone stores, and retention of calcium by the kidneys. It is therefore essential for the calcification of bones and teeth.
New research has also found Vitamin D inversely associated with the incidence of upper respiratory tract infections.

Zinc is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function , protein synthesis , wound healing , DNA synthesis , and cell division . it also supports normal growth and development during pregnancy, childhood, and adolescence and is required for proper sense of taste and smell .Zinc deficiency is characterized by growth retardation, loss of appetite, and impaired immune function. In more severe cases, zinc deficiency causes hair loss, diarrhea, delayed sexual maturation, impotence, hypogonadism in males, and eye and skin lesions . Weight loss, delayed healing of wounds, taste abnormalities, and mental lethargy can also occur

 

DOSAGE

1 tab of APPICAL BD

INDICATED BENEFITS OF APPICAL

1 Maintains strong bones and healthy teeth
2 Helps prevent osteoporosis to reduce the risk of fractures later in life
3 May help reduce high blood pressure
4 Plays a role in relieving symptoms of PMS
5 Supports colon health
7 Good for adolescents and post-menopausal women
8 Aids function of nerves and muscles, including regulation of normal heart rhythm
9 Maintains steady metabolism
10 Indicated in decreased levels of parathyroid hormone (acute and chronic)
11 Supplementation should be given for postmenopausal osteoporosis
12 helpful in rickets and osteomalacia (softening of the bones)

CONTRAINDICATIONS

APPICAL is contraindicated in patients with hypercalcaemia and/or hypercalciuria. Nephrolithiasis, hypervitaminosis D, hypophosphataemia

SPECIAL PRECAUTIONS

Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D. Caution when using in patients with history of kidney stones. Renal impairment;
frequent monitoring of serum calcium and phosphorus is recommended.

DRUG INTERACTIONS

APPICAL may affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be given at least 3 hr before calcium-containing preparations.

ADVERSE DRUG REACTIONS

APPICAL can cause Constipation, flatulence, nausea, abdominal pain and diarrhoea. Pruritus, rash and urticaria.

STORAGE CONDITIONS

Oral: Store below 25°C. Store APPICAL at room temperature



WARNING!

Be sure to consult your doctor before taking any medication!


"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Tgon-plus suspension

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

TGON-PLUS

Each 5 ml of TGON-PLUS suspension contains:

Mefenamic Acid IP  50 mg
Paracetamol IP 125 mg


CATEGORY      analgesic antipyretic and anti inflammatory agents

MODE OF ACTION

Mefenamic acid - Mefenamic acid inhibits the enzymes COX-1 and COX-2 and reduces the formation of prostaglandins and leukotrienes. It also acts as an antagonist at prostaglandin receptor sites. It has analgesic and antipyretic properties with minor anti-inflammatory activity

Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation.
It produces antipyresis by inhibiting the hypothalamic heat-regulating centre.
Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.



INDICATIONS


TGON-PLUS is indicated for temporary relief of fever and discomfort due to tonsillitis,
pharyngitis, colds and "flu", and for pain and discomfort due to teething,
immunizations and tonsillectomy.


TGON-PLUS is also useful for relief of mild to moderate painful inflammatory conditions.



DOSAGE AND ADMINISTRATION


Mefenamic acid 4 to 6.5 mg/kg per dose (maximum 25 mg/kg/day)
Paracetamol 10-15 g/kg per dose upto three times daily as necessary.



Therapy with TGON-PLUS Suspension should not exceed one week


PACKING
60 ml bottle.


SALIENT FEATURES
Mefenamic acid demonstrated significantly better antipyretic activity compared to paracetamol and ibuprofen alone.
(ref: J Assoc Physicians India. 1995 Sep;43(9):614-6)
Paracetamol has faster onset of action i.e. 30 - 60 minutes
Faster onset of action of paracetamol and longer duration of action of mafenamic acid make TGON-PLUS a very good choice in controlling pain and fever in children


WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Orfy-oz tab

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each film coated ORFY-OZ tablet contains:

Ofloxacin - 200mg
Ornidazole - 500mg

CATEGORY antibiotics

Ofloxacin  2nd generation fluoroquinolone
Ornidazole A nitroimidazole which is an antibacterial and antiprotozoal drug used to treat anaerobic enteric protozoa.

ORFY-OZ cover both aerobic and anaerobic infections effectively

INDICATIONS

ORFY-OZ is primarily indicated in conditions like
Polymicrobial mixed infections
Mixed diarrheas
Postoperative infections
Lower respiratory tract infections
Lung abscess/emphysema
Bronchiectasis
Upper respiratory tract infections
Chronic sinusitis
Purulent sinusitis
Peritonsillar abscess
Appendicitis
All abscesses
Biliary infections
Osteomyelitis
Wound infections
Infected decubitus ulcer
Immunocompromised patients
Infections in cancer patients
Gynecological infections
Dental infections
Diabetic foot infections.
Resistant enteric fever


DOSAGE
1 ORFY-OZ tab BD or As Prescribed by Physician.


CONTRAINDICATIONS
Hypersensitivity  It is not advocated during the first trimester of pregnancy and in those with history of tendinitis or tendon rupture following use of quinolones.lactation

ADVERSE DRUG REACTIONS

Ornidazole - Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity,
poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.

Ofloxacin - Nausea, vomiting, abdominal pain, diarrhoea; headache, dizziness, insomnia, hallucinations;
leucopenia and eosinophilia; vaginitis; dysgeusia; tendon damage and rupture; anorexia;
tremor; photosensitivity; hypersensitivity reactions


WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Akuspas tab

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each tablet of AKUSPAS contains:

Mefenamic Acid         250 mg
Dicyclomine HCl         20 mg


CATEGORY  anti spasmodics

Dicyclomine         antispasmodic
Mefenemic acid    traditional NSAID



INDICATIONS

AKUSPAS is indicated for

Symptomatic relief of colics such as:
-intestinal colic
-biliary colic
-ureteric colic
Dysmenorrhea.


CONTRAINDICATIONS


Hypersensitivity, G.I. ulceration,preexisting renal disease
obstructive uropathy,intestinal obstruction,severe ulcerative colitis
pregnancy,lactation and children < 6 months of age


ADVERSE DRUG REACTIONS


Mefenemic acid - diarrhea, nausea , vomiting, and abdominal pain.
Dicyclomine - GI disturbances, central nervous symptoms, hypersensitivity reactions and other skin eruptions, palpitations, tachycardia, apnea, dyspnea, asphyxia, decreased sweating, nasal stuffiness or congestion, sneezing, throat congestion, impotence, suppression of lactation, blurred vision and other eye complaints.



MODE OF ACTION


Dicyclomine - Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract.
This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle.

Mefenamic acid - Mefenamic acid inhibits the enzymes COX-1 and COX-2 and reduces the formation of prostaglandins and leukotrienes. It also acts as an antagonist at prostaglandin receptor sites. It has analgesic and antipyretic properties with minor anti-inflammatory activity.


DOSAGE


Adults: 1 AKUSPAS tab. TDS, or as prescribed.
The total dose of mefenamic acid should not exceed (1500 mg) in a day


SALIENT FEATURES



Mafenamic acid has dual mode of action in relieving pain and has mild spasmodic action in uterus.
mafenamic acid decreases menstrual blood loss by 40%
The combination of Mefenamic Acid-Dicyclomine in AKUSPAS provide relief from the severe kind of pain occurring during menstrual cycle, known as dysmenorrhea.One medicine provides analgesic effect while other relaxes the smooth muscles present in the uterus; eventually cramping feelings of severe nature are blocked.





WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Tgon drop and syrup

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each ml of TGON-100 drops contains:
paracetamol  100 mg


Each 5 ml of TGON-250 syrup contains:
paracetamol  250 mg

CATEGORY analgesic and antipyretic

INDICATIONS

Mild to moderate pain and fever
Post vaccination pyrexia

SPECIAL PRECAUTIONS

Renal or hepatic impairment, alcohol-dependent patients, G6PD deficiency.

ADVERSE DRUG REACTIONS

Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.

Potentially Fatal: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage

MODE OF ACTION
Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation.
It produces antipyresis by inhibiting the hypothalamic heat-regulating centre.
Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
Onset of action 30-60 minutes
Duration: 4-6 hr.

DOSAGE

10-15 mg/kg 6-8 hrly (max 4 doses or 60 mg/kg daily in divided doses)

PACKING

TGON 100 drops     15 ml bottle with 1 ml dropper.
TGON 250 syrup     60 ml bottle

SALIENT FEATURES
Paracetamol is a relatively safer analgesic and antipyretic than other NSAIDS
Faster onset of action - 30-60 minutes



WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Lxflo suspension

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION


Each 5 ml of LXFLO suspension contains:

Milk of Magnesia     IP 3.75 ml,
Liquid Paraffin         IP 1.25 ml,
Sodium Picosulfate BP 3.33 mg


CATEGORY  laxative 


Liquid paraffin           faecal softner/lubricant
Milk of magnesia       osmotic laxative
Sodium picosulphate  stimulant laxative


INDICATIONS


Short term treatment of constipation associated with

1 Piles
2 Anal Fissure,
3 Cardiovascular disorder
4 Hernia
5 Pre and Post operative condition
6 Endoscopy 
7 Elderly and bed ridden patients
8 Bowel clearance before radioscopy.



MODE of ACTION


LXFLO suspension contains Milk of Magnesia which increases the osmotic gradient in the gut and stimulates peristalsis resulting in efficient bowel evacuation.

Sodium picosulphate in LXFLO suspension  stimulates the propulsive activity of the colon, prevents absorption of water in the colonic lumen and thus promotes accumulation of water.

Liquid paraffin in LXFLO suspension lubricates bowel and softens the stools.



DOSAGE 2 tablespoonful at bedtime Should be taken with adequate water.


ADVERSE EFFECTS


Prolonged use or overdose of Sodium Picosulfate  can precipitate the onset of an atonic non functional colon and hypokalemia.
Liquid Paraffin may cause aspiration pneumonia, perianal pruritus and interfere with post-operative healing following anorectal surgery. Repeated use may interfere with the absorption of essential fat-soluble substance and may cause deficiency of vitamin A, D and K.
Small amount of Magnesium gets absorbed in the circulation and may cause occasional toxicity particularly in presence of kidney damage.


CONTRAINDICATION

Hypersensitivity to any ingredient; nausea, vomiting or other symptoms of appendicitis,
acute abdominal surgery, intestinal obstruction, undiagnosed abdominal pain, pregnancy and lactation.


DRUG INTERACTIONS

Laxatives containing Magnesium salt impair absorption of Tetracycline.

Since Sodium Picosulfate increases the rate of gastrointestinal transit, it may affect the absorption of other orally administered drugs which are given concomitantly.


PACKING Bottle of 100ml.


SALIENT FEATURES


Liquid paraffin is drug of choice and more effective than lactulose in the treatment of chronic functional constipation of childhood
(ref:acta medica iranica 2007;45(3):183-188)
sodium picosulphate is an effective ,well tolerated and safe laxative in acute treatment of chronic constipation.
(ref:int.journal of clinical practice,vol 61,issue 6,page 944-950,and june 2007)





WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Akuzole suspension

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each 5 ml of AKUZOLE suspension contains

Magaldrate            400 mg
Simethicone            20 mg

CATEGORY antacid


Magaldrate    antacid
Simethicone  antiflatulent


INDICATIONS


Hyperacidity
Peptic ulcer
Dyspepsia
Heart burn
Flatulence
Esophagitis



MODE OF ACTION


Magaldrate is the mixture of magnesium and aluminium salts

- Aluminium hydroxide works gradually and slowly therefore provides long lasting relief in hyperacidity
- Magnesium hydroxide rapidly neutralizes the acid therefore gives faster relief

Magaldrate provides rapid and sustained antacid effect with balanced effect on gut motility.

Simethicone

- It breaks down bubbles of gas in stomach and duodenum causing expulsion of gas by belching or in the form of flatus



DOSAGE

5-10 ml,4 times a day,15 minutes before meals and at bed time



ADVERSE DRUG REACTIONS


Constipation,diarrhoea,intestinal pain,numbness in oral mucosa,Drowsiness.


SPECIAL PRECAUTIONS


Pregnancy not recommended
Pediatrics not safe for children less than 6 years of age
Elderly should be given with caution in  patients with even moderate renal impairment.
Renal / hepatic impairment- should be avoided.



CONTRAINDICATIONS


Hypersensitivity,epilepsy,Hepatic impairment,GI haemorrhage,Obstruction and Perforation, Patients with Prolactin releasing pituitary hormone



SALIENT FEATURES


Magaldrate has 10 times higher acid neutralizing capacity than conventional antacids
simethicone antacid liquid combination protects gastric mucosa from the mucolyic effect of Hcl-pepsin-choline mixture.




WARNING!

Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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WORNO

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION


Each 5 ml of WORNO suspension contains:
Albendazole   200 mg

Each chewable micronized tablet of WORNO contains:
Albendazole - 400mg


CATEGORY anthelmintics or anti-worm medication


MECHANISM OF ACTION

Albendazole exhibits a broad-spectrum anthelmintic activity showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease (Echinococcus).


INDICATION AND DOSAGE


Echinococcosis

Adult: >60 kg: 400 mg bid for 28 days; <60 kg: 15 mg/kg daily in 2 divided doses. Max dose: 800 mg daily.

For cystic echinococcosis, up to 3 treatment cycles of 28 days each may be given with 14 treatment-free days in between cycles.

For alveolar echinococcosis, treatment cycles of 28 days each with 14 treatment-free days in between.

Treatment cycles may need to be continued for mth or yr until complete eradication of parasites.


Neurocysticercosis

Adult: >60 kg: 400 mg bid; <60 kg: 15 mg/kg daily in 2 divided doses for 8-30 days.

Max Dosage: Adult <60 kg: 800 mg daily.


Ascariasis, enterobiasis, hookworm infections or trichuriasis

Adult: 400 mg as a single dose.

Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis.

it is recommended that all household contacts of patients with enterobiasis ( pin worm ) receive treatment, especially when multiple or repeated symptomatic infections occur, since such contacts commonly also are infected


Strongyloidiasis

Adult: 400 mg once daily or bid for 3 consecutive days, repeated after 3 wk if necessary.


Giardiasis

Adult: 400 mg daily for 5 days.
Child: 400 mg daily for 5 days.



ADMINISTRATION

Should be taken with food.



OVERDOSAGE

Symptomatic and supportive measures are advised.



CONTRAINDICATIONS

Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.



SPECIAL PRECAUTIONS

Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.



ADVERSE DRUG REACTIONS

GI discomfort, headache, nausea, dizziness, allergic reactions, pruritus, raised liver enzymes, alopecia and dry mouth.
Potentially Fatal: Bone marrow depression.



DRUG INTERACTIONS

Cimetidine increases albendazole metabolism. Serum levels are increased if taken with dexamethasone and praziquantel agent.



PREGNANCY Category (US FDA)
Category C


WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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CGON-LV

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each film coated tablet of CGON-LV contains:
Levocetirizine - 5mg

Each 5ml of CGON-LV syrup contains:
Levocetirizine - 2.5mg

CATEGORY anti allergics

INDICATIONS

Seasonal allergic rhinitis
CGON-LV (levocetirizine dihydrochloride)  is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 2 years of age and older.

Perennial Allergic Rhinitis
CGON-LV(levocetirizine dihydrochloride) is indicated for the relief of symptoms associated with perennial allergic rhinitis in adults and children 6 months of age and older.

Chronic Idiopathic Urticaria
CGON-LV (levocetirizine dihydrochloride) is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older.

MODE OF ACTION
Levocetirizine (as levocetirizine dihydrochloride) is a third-generation non-sedative antihistamine, the active enantiomer of cetirizine, is an anti-histamine;
its principal effects are mediated via selective inhibition of H1 receptors

DOSAGE
Adults and Children 12 Years of Age and Older

The recommended dose of CGON-LV (levocetirizine dihydrochloride) is 5 mg once daily in the evening
Some patients may be adequately controlled by 2.5 mg once daily in the evening.

Children 6 to 11 Years of Age

The recommended dose of CGON-LV (levocetirizine dihydrochloride) is 2.5 mg  once daily in the evening.
The 2.5 mg dose should not be exceeded because the systemic exposure with 5 mg is approximately twice that of adults

Children 6 months to 5 Years of Age

The recommended initial dose of CGON-LV (levocetirizine dihydrochloride) is 1.25 mg once daily in the evening. The 1.25 mg once daily dose should not be exceeded

ADMINISTRATIONS
May be taken with or without food.

CONTRAINDICATIONS
Lactation. End-stage renal disease or haemodialysis patients. Child 6-11 yr with renal impairment.

SPECIAL PRECAUTIONS
Renal impairment. May impair ability to drive or operate machinery.

ADVERSE DRUG REACTIONS

Fatigue, somnolence, dry mouth, nasopharyngitis, pyrexia, cough, epistaxis.

DRUG INTERACTIONS
Additive sedation with alcohol and other CNS depressants.
PREGNANCY
can be given ( CATEGORY B )


WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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TGON- 2 tab

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION
Each film coated tablet of TGON-2 contains:
Aceclofenac   100 mg
Paracetamol   325 mg

CATEGORY   analgesic and anti-inflammatory

Aceclofenac - novel NSAID;selective COX-2 inhibitor.
Paracetamol - analgesic and antipyretic

TGON-2 is a potent analgesic antipyretic and anti-inflammatory properties.

MODE OF ACTION

Aceclofenac - aceclofenac when administered penetrates the inflammatory cells.it suppresses the prostaglandin synthesis by COX-2 induction which results in anti-inflammatory action i.e. no inflammation and pain.

Paracetamol - paracetamol acts by blocking the synthesis of pro-inflammatory prostaglandins and also by blocking nociceptors which results in increasing pain threshold and hence no feeling of pain.

INDICATIONS

Acute painful inflammatory conditions
Post operative inflammation
Traumatic injury
Dental pain due to infection,trauma etc
Cervical pain
Shoulder pain

DOSAGE  1 tablet BD

RISK CATEGORIES

PREGNANCY

Paracetamol-category B,aceclofenac- contraindicated in last trimester

Lactation- should be avoided

Pediatrics contraindicated
Renal/Hepatic  impairement  caution should be taken

CONTRAINDICATIONS
Hypersensitivity, G. I. Ulceration,Severe heart failure,Bleeding disorders and Asthma

ADVERSE DRUG REACTIONS

Paracetamol: Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.

Aceclofenac: Diarrhoea, headache, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blood dyscrasias.

SALIENT FEATURES

Aceclofenac   almost 100% bioavailability
                       onset of action within 30 minutes
                       better G.I. tolerability
Paracetamol   safe and well tolerated drug



WARNING!

Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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ORFY-OZ suspension

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each 5 ml ORFY - OZ suspension contains:
Ofloxacin--------- 50 mg
Ornidazole--------125 mg

CATEGORY - Anti-diarrheal

DESCRIPTION
Ofloxacin - 2nd generation fluoroquinolone, an antibacterial active against gram positive, gram negative,aerobes and atypical microorganisms

Ornidazole- 5- nitroimidazole, an antiprotozoal active against protozoa and anaerobes

MODE OF ACTION
Ofloxacin- kills bacteria by inhibiting DNA gyrase and topoisomerase 4 enzyme

Ornidazole- kills protozoa and anaerobic bacteria by producing toxic substances

INDICATIONS

ORFY-OZ suspension is indicated in-
1 Severe diarrohea
2 amoebic dysentery
3 bacillary dysentery
4 mixed dysentery

DOSAGE

Ofloxacin 7.5 mg/kg /dose BD
Ornidazole 25 mg/kg/day BD

ADVERSE EFFECTS

ORFY-OZ suspension can cause nausea, vomitings,headache, abdominal pain etc

SALIENT FEATURES

No metallic taste
Better efficacy

PACKING

ORFY-OZ suspension comes in 30 ml and 50 ml suspension

WARNING!
Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Tgon - MR tab

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each film coated tablet of TGON-MR contains

Aceclofenac       100 mg
Paracetamol       325 mg
Chlorzoxazone    250 mg

CATEGORY   analgesic and anti-inflammatory with muscle relaxant


Aceclofenac - novel NSAID;selective COX-2 inhibitor.
Paracetamol - analgesic and antipyretic
Chlorzoxazone - an efficient muscle relaxant


TGON-MR is a potent anti-inflammatory and analgesic with advantage of muscle relaxant property of chlorzoxazone.

MODE OF ACTION

Aceclofenac - aceclofenac when administered penetrates the inflammatory cells.aceclofenac suppresses the prostaglandin synthesis by COX-2 induction which results in anti-inflammatory action i.e. no inflammation and pain.

Paracetamol - paracetamol acts by blocking the synthesis of pro-inflammatory prostaglandins and also by blocking nociceptors which results in increasing pain threshold and hence no feeling of pain.

Chlorzoxazone - it acts at the level of the spinal cord and results in inhibiting the message transfer through motor neurons.thus gives relief from muscular pain


INDICATIONS

Painful muscle spasm associated with musculoskeletal conditions
Sprain
Strain
Cervical pain - neck pain
Shoulder pain
Lumbago low back pain
Dental pain
Primary dysmenorrhoea - painful menstrual cycle
Ankylosing spondylitis- spinal arthritis

ADMINISTRATION
Should be taken with food.

CONTRAINDICATIONS
Hypersensitivity, Moderate to severe renal or hepatic impairment, severe heart failure, Porphyria. Lactation ,pregnancy (third trimester).

SPECIAL PRECAUTIONS
GI disease; renal or hepatic impairment; alcohol-dependent patients; asthma or allergic disorders; haemorrhagic disorders; hypertension; cardiac impairment.
Elderly. Caution when driving or operating machinery. Monitor renal and hepatic function and blood counts during long term treatment.
Persistently elevated hepatic enzyme levels may require drug withdrawal. Pregnancy, lactation.

ADVERSE DRUG REACTIONS

Paracetamol: Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.

Aceclofenac: Diarrhoea, headache, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blood dyscrasias.

chlorzoxazone Drowsiness, dizziness, lightheadedness, headache, excitement, restlessness, GI disturbances, irritability, sensitivity reactions (skin rash). Jaundice, liver damage reported. Orange or reddish-purple urine.

DOSAGE      1 tab BD


SALIENT FEATURES

Aceclofenac - a novel NSAID with multiple mode of actions,rapid onset of action i.e.30 min. with 100% bioavailability It is ell tolerated with comparatively lower G.I. side effects than conventional NSAIDS

Paracetamol- safe and trusted analgesic

Chlorzoxazone - an efficient muscle relaxant

TGON-MR provides faster relief in pain

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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IGON-PLUS tab

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each uncoated tablet of  IGON-PLUS 100 contains:
cefixime  100 mg
ofloxacin 100 mg


Each film coated tablet of  IGON-PLUS contains
cefixime   200 mg
ofloxacin  200 mg

CATEGORY antibiotic
        
MODE OF ACTION

CEFIXIME
Cefixime is a 3rd generation cephalosporin.it binds with target proteins in bacterial cell wall ,interferes with synthesis of peptidoglycans making the cell wall weak and ultimately bursting and  death of the cell.

OFLOXACIN
Ofloxacin is a 2nd generation fluoroquinolone it blocks the DNA Gyrase and DNA topoisomerase 4 causing cell death.

INDICATIONS
1 Resistant typhoid fever
2 pyrexia of unknown origin

DOSAGE
Adults
1 tab of IGON-PLUS B.D. FOR 7-14 days

children
1 tab of IGON-PLUs 100 B.D.  for 7-14 days

safety in children
above 1 year

pediatric dosage
Cefixime 20mg/kg/day in 2 divided doses
( antimicrob agents chemother.2001 sep.45(9):2450-2454)

Ofloxacin 15 mg/kg/day in 2 divided doses
( ref: antimicrobial agent and chemotherapy,april 1996,p.958-961)

CONTRAINDICATIONS
pregnancy ,lactation,hypersensitivity to either cefixime or ofloxacin.

ADVERSE DRUG REACTIONS

loose stools,abdominal pain,nausea,dyspepsia,flatulence etc.

SALIENT FEATURES

Synergistic effect in eradication of salmonella typhi.
Clinical efficacy around 100%
Lesses chances of relapse
Both drugs are WHO approved for the treatment of typhoid fever.
Fever clearance time 3 days
Cefixime and ofloxacin are having excellant efficacy in UTI with 94% success rate

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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TGON-2 suspension

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each 5 ml of TGON-2 contains
Ibuprofen                      100 mg
Paracetamol               162.5 mg

CATEGORY analgesic,antipyretic and anti-inflammatory

INDICATIONS

Fever
Mild to moderate pain
Pain and inflammation associated with musculoskeletal and joint disorders.

MODE OF ACTION

Ibuprofen blocks COX enzyme that is responsible for the synthesis of pro-inflammatory prostaglandins
paracetamol increases pain threshold and also blocks pyrogens

DOSAGE

dose of paracetamol 15 mg/kg/dose q 6hly


CONTRAINDICATIONS

Active peptic ulcer, history of hypersensitivity to either component, recent GI bleeding, neonates.

SPECIAL PRECAUTIONS

Bronchial asthma, renal or hepatic disorders, bleeding disorders, CV diseases, hypertension, patients on anticoagulants, aspirin/NSAIDs induced allergy, pregnancy & lactation.

ADVERSE DRUG REACTIONS

Dyspepsia, heart burn, GI bleeding, rash, asthmatic attacks, thrombocytopenia,
drug induced ulcer, drowsiness, hepatic necrosis, renal papillary necrosis, vision disturbances & disorientation; rarely nausea & vomiting can occur.
Potentially Fatal: Hematemesis, agranulocytosis, severe allergic reaction.

SALIENT FEATURES

ibuprofen and paracetamol combination is more effective in pyrexia than paracetamol
(ref:BMJ 2006;334:4-5)

TGON-2 has rapid antipyretic effect

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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AKUZOLE tab

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each tablet of AKUZOLE  contains
pantoprazole                              40 mg


CATEGORY   antacids-proton pump inhibitor (PPI), blocks 100% acid secretion.

INDICATIONS

Gastric ulcers
Deudenal ulcers
GERD
Hyperacidity

MODE OF ACTION

Pantoprazole inhibits H⁺/K⁺ ATPase pump function thereby reducing gastric acid secretion. It also has a role in the eradication of H. pylori

DOSAGE

Hyperacidity 40 mg once daily 2-4 wks


Peptic ulcer 40 mg once daily
Duration: Duodenal ulcers: 2-4 wks; Gastric ulcers: 4-8 wks.

NSAID-associated ulceration 20 mg daily.

Eradication of H. pylori infection Triple therapy: 40 mg bid combined with clarithromycin 500 mg bid and either amoxicillin 1 g bid or metronidazole 400 mg bid.

GERD 20-40 mg once daily in the morning for 4 wk, increased to 8 wk if necessary.
Maintenance: 20-40 mg daily, increased to 40 mg each morning if symptoms return


Zollinger-Ellison syndrome Initially 80 mg daily, adjusted to individual requirements. Up to 240 mg daily may be used if needed. Daily doses >80 mg should be given in 2 divided doses



ADMINISTRATION

May be taken with or without food


SPECIAL PRECAUTIONS

Long-term therapy may lead to bacterial overgrowth in the GI tract. Hepatic impairment; monitor liver function regularly (if enzymes increase, discontinue); pregnancy ( category-B ) ; not recommended in children <18 yr; long term use may lead to atrophic gastritis


CONTRAINDICATIONS

Lactation


ADVERSE DRUG REACTIONS

Diarrhoea, dizziness, pruritus, skin rashes, GI tract infections, chest pain, headache, nausea, pain, anxiety, hyperglycaemia; malaise or lassitude; myalgia; oedema; insomnia; hyperlipidaemia; flatulence, abdominal pain, constipation, eructation, dyspepsia, rectal disorder; urinary frequency, UTI; abnormalities in liver function; local site reaction; hypertonia, neck pain, weakness; bronchitis, cough, dyspnoea, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, flu syndrome.

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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ORFY L

COMPOSITION

Each film coated tablet of ORFY L-250 contains:
levofloxacin             250 mg

Each film coated tablet ORFY L-500 contains:
levofloxacin             500 mg

CATEGORY antibiotics- 3rd generation oral fluoroquinolone.


INDICATIONS  /  DOSAGE

Acute sinusitis                                    500 mg OD for 10-14 days.

Acute bacterial exacerbation of chronic bronchitis
                                                           500 mg OD for 7 days.

Community-acquired pneumonia        500 mg OD for 7-14 days.

Uncomplicatd skin infections               500 mg OD for 7-10 days.

Nosocomial pneumonia;Complicated skin infections  
                                                             750 mg OD for 7-14 days.

Uncomplicated UTI                               250 mg OD for 3 days.

Acute pyelonephritis;Complicated UTI
                                                              250 mg OD for 10 days.

Chronic bacterial prostatitis                   500 mg OD for 28 days.

MDR - TB                                               750 mg od x 24 months

MODE OF ACTION
levofloxacin kills bacteria by inhibiting DNAgyrase and DNA topoisomerase 4 enzyme.

ADMINISTRATION

May be taken with or without food. (Ensure adequate fluid intake.)

ADVERSE DRUG REACTIONS
Nausea, diarrhoea, constipation, headache, insomnia


CONTRAINDICATIONS
hypersensitivity to levofloxacin,Child <18 yr.

PRECAUTIONS
Pregnancy ( CATEGORY C ) and lactation.

SALIENT FEATURES
Convenient od dosage schedule
It is a drug of choice in UTI - 99% boiavailability and >87% excreted in urine unchanged.
Levofloxacin 750 mg od for 5 days is as  effective as ten days course of the therapy with ciprofloxacin 400 mg iv or ciprofloxacin 500 mg orally twice daily for the treatment of acute pyelonepheritis and complicated UTI
Shows higher bactericidal activity as compared to ofloxacin
( ref: j antimicrob agents chemother 1997,39,719-723)
offers MIC 90 values 50% lower than those observed with ofloxacin.



WARNING! Be sure to consult your doctor before taking any medication!

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IGON-O

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION


IGON-O 100
Each uncoated dispersible tablet contains:
cefpodoxime proxetil
eq. to Cefpodoxime              100 mg


IGON-O 200
Each film coated tablet contains:
cefpodoxime proxetil
eq. to Cefpodoxime               200 mg


IGON-O dry syrup
Each 5 ml of reconstituted suspension contains:
cefpodoxime proxetil
eq. to Cefpodoxime                 50 mg


IGON-O drops
Each ml of reconstituted suspension contains:
cefpodoxime proxetil
eq.to Cefpodoxime                    25 mg


CATEGORY   antibiotics-3rd generation oral cephalosporin


INDICATIONS


1 Respiratory tract infections
2 Skin and soft tissue infections
3 Urinary tract infections
4 Sexually transmitted disease
5 Enteric fever


MODE OF ACTION


Bactriocidal - IGON - O kills bacteria by inhibiting cell wall synthesis by binding to target protein.


DOSAGE
Pharyngitis                                                          100 mg BD x 5-10 days
Tonsillitis                                                             100 mg BD x 5-10 days
Community Acquired Pneumonia (CAP)               200 mg BD x 14 days
Skin and Soft Tissue Infections                           400 mg BD x 7-14 days
Uncomplicated UTI                                               100 mg BD x 7 days
Sexually Transmitted Diseases (STD)
Uncomplicated gonorrhea                                    200 mg single dose
Acute Bacterial Exacerbation of Chronic Bronchitis (AECB)
                                                                            200 mg BD x 10 days
( ref: drugs facts and comparison.2006.60th edition,pg no.1569)

Pediatric dose
10 mg /kg/day q 12 hr
(ref: nelson textbook of pediatrics 17th ed.page 2487)

In typhoid fever
10-20 mg/kg/day
( ref: the indian journal of pediatrics 2004.vol 71 issue 5 pg.no 413-415)

cefpodoxime showed 86% efficacy in the treatment of typhoid fever in children
( ref: the indian j. of pediar,2004,vol 71,issue 5 pg 413-415)

cefpodoxime can be given to children and infants ages 15 days and older in a dose of 4 mg - 5 mg /kg every 12 hrs,for infections of respiratory tract ,urinary tract and skin and soft tissues.
(ref: martindale,35th ed.pg no 207)

 CONTRINDICATIONS

 Hypersensitivity to cefpodoxime.

SPECIAL PRECAUTIONS

History of allergy to penicillin; severe renal impairment; pregnancy and lactation.

ADVERSE DRUG REACTIONS

Anaphylactic shock; purpuric nephritis, skin rash, pruritus; diarrhoea, nausea, abdominal pain, vomiting.
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.

DRUG INTERACTIONS

Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion.
Potentially Fatal: Monitor renal function during admin. Additive nephrotoxic effects with furosemide.


SALIENT FEATURES

- USFDA approved in acute otitis media and acute sinusitis.

- Better healing rates than cefixime and coamoxyclav in painful otitis media.
(ref: pediatr infect dis j.1995april;14( 4 suppl): s 12-8

- Broadest spectrum among all oral beta-lactam antibiotics.
( infection.1984 sep-oct;22(5):370-5)

- Less chances ( 3.4% )of diarrhoea than cefixime ( 13% )

- Ten times higher potency than cefixime against s.pneumoniae
( int.j.antimicrobial agents, vol 25, issue 2, feb 2005,pg 120-129)

- More potent than cefaclor,cefixime against pneumococci.

- Cefpodoxime is the only third generation cephalosporin with activity against s. aureus.

- Can be given in pregnancy ( category B)

- Cefpodoxime showed 86% efficacy in the treatment of typhoid fever in children
( ref: the indian j. of pediar,2004,vol 71,issue 5 pg 413-415)

- Cefpodoxime is safe even in 15 days old child.
(ref: martindale,35th ed.pg no 207)

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

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Jiggoo-D cough syrup

For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only

COMPOSITION

Each 5 ml of JIGGOO-D syrup contains:

Dextromethorphan                         10 mg
Ammonium chloride                       60 mg
Guaiphenesin                                  50 mg
Chlorphenaramine maleate            2.5 mg

CATEGORY cough suppressant

INDICATIONS
Cough associated with respiratory tract infections ,allergies and smoking ( both productive and non productive cough )

MODE OF ACTION

DEXTROMETHORPHAN

Dextromethorphan  is a cough suppressant ( antitussive ),it acts on the cough center in medulla and increases threshold of the cough center.  suppressing the frequency and intensity of the cough.

CHLORPHENIRAMINE MALEATE

chlorpheniramine is H1 histamine receptor blocker,it blocks the H1 receptors in respiratory tract mucosa and relieves the allergic symptoms.

GUAIPHENESIN

Guaiphenesin is an expectorant .it reduces the viscosity of thick and sticky sputum,thereby decreasing the intensity and frequency of cough and helps in expectoration.

AMMONIUM CHLORIDE

Amonium chloride increases the respiratory tract fluid secretions,reduces viscosity of mucous,removes tenacious mucous/congestion and helps in productive / non productive cough.

DOSAGE

ADULTS                           1-2 tsf 3-4 times daily
CHILDREN                         1/2-1 tsf thrice daily

SALIENT FEATURES:

JIGGOO- D is a non addictive and non sedating cough preparation

WARNING!

Be sure to consult your doctor before taking any medication!

"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"

Read more »