For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only
COMPOSITION
Each uncoated tablet of IGON-PLUS 100 contains:
cefixime 100 mg
ofloxacin 100 mg
Each film coated tablet of IGON-PLUS contains
cefixime 200 mg
ofloxacin 200 mg
CATEGORY antibiotic
MODE OF ACTION
CEFIXIME
Cefixime is a 3rd generation cephalosporin.it binds with target proteins in bacterial cell wall ,interferes with synthesis of peptidoglycans making the cell wall weak and ultimately bursting and death of the cell.
OFLOXACIN
Ofloxacin is a 2nd generation fluoroquinolone it blocks the DNA Gyrase and DNA topoisomerase 4 causing cell death.
INDICATIONS
1 Resistant typhoid fever
2 pyrexia of unknown origin
DOSAGE
Adults
1 tab of IGON-PLUS B.D. FOR 7-14 days
children
1 tab of IGON-PLUs 100 B.D. for 7-14 days
safety in children
above 1 year
pediatric dosage
Cefixime 20mg/kg/day in 2 divided doses
( antimicrob agents chemother.2001 sep.45(9):2450-2454)
Ofloxacin 15 mg/kg/day in 2 divided doses
( ref: antimicrobial agent and chemotherapy,april 1996,p.958-961)
CONTRAINDICATIONS
pregnancy ,lactation,hypersensitivity to either cefixime or ofloxacin.
ADVERSE DRUG REACTIONS
loose stools,abdominal pain,nausea,dyspepsia,flatulence etc.
SALIENT FEATURES
Synergistic effect in eradication of salmonella typhi.
Clinical efficacy around 100%
Lesses chances of relapse
Both drugs are WHO approved for the treatment of typhoid fever.
Fever clearance time 3 days
Cefixime and ofloxacin are having excellant efficacy in UTI with 94% success rate
WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"
Posted in: ANTIBIOTIC,CEFIXIME,IGON PLUS,OFLOXACIN,TYPHOID FEVER
